Table 2.

SN and ECN functional connectivity during acute stress (RS1) and the aftermath of stress (RS2)

Scan session	Brain region	Peak T value	Cluster size (mm3)	MNI coordinates (x,y,z)
SN
RS1	Group × stress interaction
	Insula, R	4.10	1120*††	40, −12, 8
	Stress > no-stress
	–
	No-stress > stress
	–
	Con-stress > Con-no-stress
	Insula, R	3.88	896*†	34, −8, −12
	Con-stress > Sib-stress
	Insula, R	3.43	24#	40, −2, 16
		3.30	32#	38, −8, 18
RS2	Group × stress interaction
	Insula, L	3.82	400†	−38, −18, 6
		3.54	168#	−38, −2, −12
	Stress > no-stress
	–
	No-stress > Stress
	Insula, L	3.97	232*†	−34, 8, 14
	Sib-no-stress > Sib-stress
	Insula, L	3.85	288†	−34, 6, 12
		3.45	368†	−40, −18, 2
ECN
RS1	Group × stress interaction
	–
	Stress > no-stress
	–
	No-stress > stress
	–
RS2	Group × stress interaction
	–
	Stress > no stress
	Cerebellum lobule VI, L	4.69	5656**	−20, −56, −32
	Cerebellum lobule VI, R, extending to fusiform gyrus	3.93	3392*	32, −40, −20
	No-stress > stress
	–

MNI, Montreal Neurological Institute; R, right; L, left; Sib, sibling of schizophrenia patient; Con, control participant.

All effects are analyzed using cluster-level statistics, using a cluster-forming threshold of p < 0.001 uncorrected at the voxel level. For pairwise comparisons, only contrasts yielding significant clusters are displayed. ** p < 0.01 (whole brain corrected), * p < 0.05 (whole brain corrected); †† p < 0.01 (small-volume corrected for region of interest); † p < 0.05 (small-volume corrected for region of interest); ^# p < 0.1 (small volume corrected for region of interest).

Reported cluster sizes represented the size of a significant cluster after corrected for a small volume unless the cluster was significant at the whole brain level only.