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. 2021 May 24;22(1):556. doi: 10.3892/ol.2021.12817

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Integrin α5 is highly expressed in 827/IcoR and PC9/IcoR cells. (A) Top 20 signaling pathways that were upregulated in PC9/IcoR compared with PC9 were screened using KEGG pathway enrichment analysis. (B) A total of four genes, including integrin α5 and integrin β4, were obtained as the intersection of the three pathways using Venn diagram. (C) Protein expression of integrin α5 and integrin β4 of HCC827, 827/IcoR, PC9 and PC9/IcoR cells by western blotting. **P<0.01. IcoR, icotinib-resistant; tRNA, transfer RNA; ECM, extracellular matrix; SPP1, secreted phosphoprotein 1; ITGB4, integrin β4; COL6A1, collagen alpha-1(VI) chain; ITGA5, integrin α5.