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. 2021 May 24;22(1):556. doi: 10.3892/ol.2021.12817

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Integrin α5 promotes migration, invasion and icotinib resistance in 827/IcoR and PC9/IcoR cells. (A) Western blotting was used to detect integrin α5 expression in 827/IcoR and PC9/IcoR transfected with the siNC or the siITGA5. (B) Transwell migration assays of 827/IcoR and PC9/IcoR with transient integrin α5-knockdown. (C) Transwell migration assay of resistant cells with or without treatment of icotinib after transfection with the siNC or the siITGA5 for 24 h (magnification, ×200). (D) Effect of icotinib treatment on cell viability after transfection with the siNC or the siITGA5 for 24 h in 827/IcoR and PC9/IcoR, assessed using MTT assays. **P<0.01. IcoR, icotinib-resistant; si-, small interfering; ITGA5, integrin α5; NC, negative control.