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. 2021 May 24;22(1):556. doi: 10.3892/ol.2021.12817

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Integrin α5/FAK-STAT3/AKT signaling pathway enhances icotinib resistance-associated malignancy. (A) Expression of proteins in the conventional pathway downstream of integrin in icotinib-resistant cells compared with parent cells. (B) Upregulated genes of resistant cells treated with or without icotinib in parent and resistant cells were analyzed using western blotting. (C) Western blotting of p-FAK, p-STAT3 and p-AKT in integrin α5-knockdown 827/IcoR and PC9/IcoR cells. *P<0.05 and **P<0.01. FAK, focal adhesion kinase; p-, phosphorylated; IcoR; icotinib-resistant; n.s., not significant.