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Fast luminescent affordable sensor of Hip1 (FLASH). (A) Following proteolytic cleavage of the FLASH probe by Mtb Hip1, self-elimination and chemiexcitation steps ultimately lead to light emission. (B) Mtb produces Hip1 protease which cleaves the FLASH probe, producing light. (C) Light produced by probe cleavage is measured over time. Total light output in a given time period (dashed area) is summed to yield integrated luminescence.
