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. 2021 Apr 15;7(5):892–899. doi: 10.1021/acscentsci.1c00181

Figure 2.

Figure 2

DNA loading capacity of various liposome scaffolds. The DNA loading onto liposomes was assessed using native gel electrophoresis and Cy5-labeled DNA. L-SNAs can be successfully formed using liposomes comprised of all phospholipids tested (DOPC, DMPC, DPPC, and DSPC) at DNA loadings of up to 100 strands per particle, as evidenced by the reduction in DNA mobility without the presence of unincorporated DNA, following incubation of cholesterol-functionalized, Cy5-labeled DNA with liposomes at T > TC for all constructs.