Table 5.

Multivariable Cox regression analysis for PFS and OS.

		Progression free survival				Overall survival
		adjusted HR	95%CI	P		adjusted HR	95%CI	P
0w	ECOG PS				CEA(ng/ml)
	2	1			≤ 3.5	1
	0	0.160	0.050-0.515	0.002	> 3.5	0.611	0.388-0.963	0.034
	1	0.217	0.077-0.612	0.004
	Radiotherapy
	No	1
	Yes	0.536	0.359-0.800	0.002
6w	ECOG PS				CEA
	2	1			Up	1
	0	0.126	0.038-0.415	0.001	Down	0.543	0.339-0.871	0.011
	1	0.207	0.072-0.592	0.003	NSE
	Radiotherapy				Up	1
	No	1			Down	0.619	0.386-0.994	0.047
	Yes	0.562	0.375-0.841	0.005
	NLR
	Up	1
	Down	0.610	0.411-0.907	0.015
	CEA
	Up	1
	Down	0.477	0.320-0.710	0.000
12w	ECOG PS				CEA
	2	1			Up	1		0.043
	0	0.129	0.038-0.437	0.001	Down	0.620	0.390-0.986
	1	0.224	0.077-0.649	0.006	NSE
	Radiotherapy				Up	1		0.029
	No	1			Down	0.578	0.353-0.947
	Yes	0.569	0.375-0.865	0.008
	NLR
	Up	1
	Down	0.587	0.388-0.886	0.011
	CEA
	Up	1
	Down	0.406	0.270-0.609	0.000

ECOG, Eastern Cooperative Oncology Group; PS, performance status; NLR, neutrophil-to-lymphocyte ratio; CEA, carcinoembryonic antigen; NSE, neuron-specific enolase.