Figure 3.

Experiment 2: BNST CRFR1 antagonist effect on fentanyl seeking during acute withdrawal (Day 5) test. (A) Day 5 incubation test data showing cues earned on FR1, 20 s to schedule. (B) Inter cue interval (ICI), the time between presses that result in cues. (C) Cumulative cues earned pattern of a representative pair of vehicle ($\overline{\mathit{\text{X}}}$ = 1.52) and R121919 ($\overline{\mathit{\text{X}}}$ = 2.75) injected rat. (D) Number of bouts. A bout is defined as two or more presses for which the interval between successive presses did not exceed 20 s. *p < 0.05, **p < 0.01, main effect of treatment. All the inset graphs indicate mean ± SEM when collapsed across dependence. ND, non-dependent; D, dependent. Data are mean ± SEM.