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. 2021 May 28;11(6):e428. doi: 10.1002/ctm2.428

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© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Donepezil modifies protein network in MS^hTau mice. (A) Heatmap showing dysregulated MS proteins induced by hTau accumulation and its modification by donepezil treatment. Ratios ≥1.2 or ≤0.83. (B) Venn diagram represents the number of differentially expressed proteins (DEPs) identified among the groups. (C–G) Forty‐one DEPs between vec:veh versus hTau:veh and hTau:veh versus hTau:DZ (low dose) (C), their changing trends (D, F), and the top 10 changed proteins in D and F (E, G). (H–L) Nineteen DEPs between vec:veh versus hTau:veh and hTau:veh versus hTau:DZ (high dose) (H), their changing trends (I, K), and the two or top 10 changed proteins in I and K (J, L)