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Functional analysis of MPL L265F on pSTAT3/STAT3, pAKT/AKT and pERK/ERK. Ba/F3 cells were infected with lentivirus overexpressing WT MPL, L265F or W515L pathogenic variant. Four days later, infected cells were treated with TPO (5 ng/ml) for 15 min. Representative (A) and quantification (B–C) of western blot is acquired from three independent experiments. Two-way analysis of variance was performed; *PBonferroni < 0.05.
