Scheme 1. Biosynthesis of bosamycins. (A) Genetic organization of the bsm gene cluster, (B) relative location of cosmid pHG06015, (C) proposed biosynthetic pathway for bosamycins, (D) biosynthesis of 3-OH aspartic acid, and (E) biosynthesis of 5-OMe tyrosine. A, adenylation domain; T, thiolation domain; C, condensation domain; E, epimerization domain; TE, thioesterase domain; and P450, cytochrome P450 monooxygenase domain.
