Abstract
The suppression of the endogenous serum Cortisol level by a single i. m. injection of 3 mg betamethasone depot (Celeston Chronodose∞) prior to orthopaedic surgical interventions on the forelimbs of 8 dogs was studied in a placebo–controlled cross–over trial. Compared to placebo the endogenous serum Cortisol level was significantly (p < 0.05) reduced for a period of 4 days, and then returned to the pre–operative range. During the 28–day observation period after each surgical intervention no impairment of wound healing, bleeding episodes or side–effects which could be attributed to the glucocorticoid, was seen.
Keywords: Cortisol suppression, wound healing.
Sammendrag
3 mg betamethasons (Celeston Chronodose®) evne til å undertrykke det endogene serum cortisol speil ble undersøkt etter engangs administrasjon før ortopedisk kirurgiske inngrep på forpotene hos 8 hunder i en placebo kontrollert, dobbelt blind overkryssningsstudie. 3 mg betamethason gav en statistisk signifikant (P < 0.05) undertrykking av det endogene serum cortisol nivå for en periode av 4 dager etter administering. I løpet av den 28 dager lange observasjonsperioden etter hvert kirurgisk inngrep ble det ikke registrert noen forstyrrelse av sårheling, blødningsepisoder etter bivirkninger som kunne tilbakeføres til forsøkspreparatet. Engangs administering av en depotformulering med 3 mg betamethason til hunder før ortopedisk kirurgiske inngrep gir en forbigående undertrykking av det endogene serum cortisol nivå som ikke er forbundet med noen klinisk påvisbare forstyrrelser av den post-operative sårheling.
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Acknowledgments
This work was supported by the Norwegian Agency for International Development (NORAD). The authors are grateful to Professor O. Aalen for statistical advice and to the Staff at the Laboratory of Endocrinology, Medical Department B, National Hospital, Oslo, Norway for the serum Cortisol analyses.
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