Table 2.
Association between qPCR-detectable P. falciparum or P. vivax infection and antibody response
| Contemporaneous infection | Infection at next presentation | |||||
|---|---|---|---|---|---|---|
| aORa | (95%CI) | p value | aORb | (95%CI) | p value | |
| PfAMA1 IgG | ||||||
| Seropositive | 0.70 | (0.52, 0.93) | 0.01 | 0.98 | (0.53, 1.80) | 0.95 |
| Level (log2OD 450nm) | 0.94 | (0.84, 1.06) | 0.34 | 0.91 | (0.73, 1.10) | 0.33 |
| PfMSP2 IgG | ||||||
| Seropositive | 0.81 | (0.61, 1.08) | 0.15 | 1.27 | (0.70, 2.29) | 0.43 |
| Level (log2OD 450nm) | 0.88 | (0.80, 0.96) | 0.005 | 0.92 | (0.77, 1.11) | 0.40 |
| PfCSP IgG | ||||||
| Seropositive | 0.51 | (0.35, 0.76) | 0.001 | 0.29 | (0.07, 1.21) | 0.09 |
| Level (log2OD 450nm) | 0.90 | (0.83, 0.98) | 0.02 | 1.02 | (0.85, 1.24) | 0.81 |
| PvAMA1 IgGc | ||||||
| Seropositive | 1.02 | (0.73, 1.43) | 0.89 | – | ||
| Level (log2OD 450nm) | 0.98 | (0.86, 1.12) | 0.75 | – | ||
Adjusted for aage (years), sex, region, residential status, time (discrete month) and repellent distribution or bage (years), sex, region, residential status, time since the last measurement (days) and repellent distribution; conly contemporaneous IgG level/seropositivity exposures were estimated for P. vivax infections due to a small number of events for individuals with measurements performed on at least two occasions. Estimates for antigen- specific IgG seropositivity or level are derived from separate equations, (Additional File 2 Tables S3-S10)
aOR adjusted odds ratio, 95%CI 95% confidence interval