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. 2021 May 28;45(5):261–270. doi: 10.1016/j.medine.2021.02.005

Figure 4.

Figure 4

Detection of SARS-CoV-2 and characterization of inflammation. (A) Edema of alveolar walls and atypical pneumocytes with enlarged nuclei (arrow). Hematoxylin–eosin staining. (B) SARS-Cov-2 mRNA detection in atypical pneumocytes by in situ hybridization. (C) Viral nucleocapsid protein detection in atypical pneumocytes by immunohistochemistry. (D) Multiplex chromogenic detection by DAB staining (brown) of CD20+ lymphocytes, purple staining of CD8+ lymphocytes, teal staining (blue) of CD4+ lymphocytes and yellow staining of macrophages. CD4+ lymphocytes outnumber CD8+ lymphocytes in this case. The scale bar corresponds to 50 μm.