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. 2021 May 25;35:20587384211000544. doi: 10.1177/20587384211000544

Figure 3.

Figure 3.

High-dose rapamycin activated Raf1-MEK-ERK in MCs. (a) Akt(Thr308), Akt(Ser473), Raf1, and ERK1/2 phosphorylation status in starved (24 h, 0.1% FBS) MCs treated with vehicle or rapamycin (1000 nmol/L, 2 h) and stimulated with PDGF-BB (20 ng/mL, 2 h; n = 3). (b) Effect of rapamycin treatment (100 and 1000 nmol/L, 2 h) and/or UO126 (10 µmol/L, 2 h) on ERK and p70S6K phosphorylation in MCs (n = 3).

The data are presented as the mean ± SD.

**P < 0.01 versus control.

#P < 0.05. ##P < 0.01 versus PDGF.

&&P < 0.01 versus PDGF+rapamycin at 1000 nmol/L.