Table 2.
Association between TMPRSS2 variant and severity using the dominant and recessive genetic models.
| Type of Comparison |
Minor Allele (A) Frequency |
Model |
Genotype |
Controls |
Patients |
P value |
Odds Ratio |
95% CI |
P value |
|
|---|---|---|---|---|---|---|---|---|---|---|
| Lower | Upper | |||||||||
| Controls Vs Asymptomatic | 0.27 Vs 0.31 | Dominant | GG Vs (GA + AA) | 277 and 223 | 139 and 160 | 0.01 | 0.69 | 0.52 | 0.93 | 0.01 |
| Recessive | (GG + GA) Vs AA | 457 and 43 | 273 and 26 | 0.96 | 0.98 | 0.59 | 1.64 | 0.96 | ||
| Asymptomatic Vs Mild to Moderate | 0.31 Vs 0.21 | Dominant | GG Vs (GA + AA) | 139 and 160 | 74 and 45 | 0.003 | 1.89 | 1.22 | 2.92 | 0.004 |
| Recessive | (GG + GA) Vs AA | 273 and 26 | 116 and 3 | 0.02 | 3.68 | 1.09 | 12.40 | 0.03 | ||
| Asymptomatic Vs Severe | 0.31 Vs 0.19 | Dominant | GG Vs (GA + AA) | 139 and 160 | 56 and 36 | 0.01 | 1.79 | 1.11 | 2.88 | 0.01 |
| Recessive | (GG + GA) Vs AA | 273 and 26 | 92 and 0 | 0.003 | 17.92 | 1.08 | 297.07 | 0.04 | ||
Genotype GG is wild type, GA is heterozygous and AA homozygous mutant. “A” allele was considered as protective. To obtain Odds ratio, we compared the genotypes between Controls Vs Asymptomatic; Asymptomatic Vs Mild to moderate and Asymptomatic Vs Severe categories under Dominant and Recessive genetic models.