Table 3.

Neuropsychiatric disorders of reported variants in different regions of the CK2α protein

Individual			Mutation	Reference	Age (y)	Sex	NPD
No.	Structural domain						Seizure	Dystonia	ASD	ADHD	Sleep	Temper	MD	ID/GDD	Score
1	ATP/GTP binding loop	1	p.R47Q	5	6.1	M			+	+	+			+	4
2		2	p.R47Q	3	6	F		+		+		+	+	+	5
3		3	p.R47Q	11	2	F	+	+			+		+	+	5
4		4	p.Y50S	3	2	F	+	+	+				+	+	5
5		5	p.Y50C	13	8	M	+	+	+	+	+	+	+	+	8
6		6	p.Y50C	12	5	F		+	+	+	+	+	+	+	7
7		7	p.S51R	11	4	M	+	+	+	+	+	+	+	+	8
8		8	p.S51Y	5	11.1	F								+	1
9	Basic cluster	1	p.V73E	11	8	M					+			+	2
10		2	p.R80H	5	10.7	M		+	+			+		+	4
11		3	p.R80C	Current report	2	M								+	1
12	Active site	1	p.D156H	9	7	M				+	+			+	3
13	Non-specific kinase domain	1	c.824 + 2T>C	3	13	F		+		+	+				3
14		2	p.P231R	11	4	M		+	+		+			+	4
15		3	p.R312W	5	6	F		+	+			+			3
16		4	p.R312Q	11	14	M								+	1
17		5	p.H160R	Current report	3	F	+								1
18	Non-kinase domain	1	p.M1V	11	2.5	F			+				+	+	3
19		2	p.E27K	11	14	M		+	+		+		+	+	5
20		3	c.1061-1G>C	7	1	M			+		+		+		3
21	Activation segment	1	p.I174M	5	10.9	M		+	+					+	3
22		2	p.R191Q	5	10	F		+						+	2
23		3	p.D175G	8	1.7	M		+			+				2
24		4	p.R191*	4	1.7	M	+	+							2
25		5	p.K198R	10	8	M		+		+			+	+	4
26		6	p.K198R	4	15	F	+	+						+	3
27		7	p.F197I	5	8	F								+	1
28		8	p.K198R	5	7.3	F	+	+	+				+	+	5
29		9	p.K198R	5	10.9	M								+	1
30		10	p.K198R	5	18.3	M	+	+						+	3
31		11	p.K198R	5	18.7	F		+						+	2
32		12	p.K198R	11	5	M									0
33		13	p.K198R	3	4.5	F		+				+		+	3
34		14	p.K198R	14	6.8	M				+		+		+	3
35		15	p.D175G	3	4	F	+				+		+	+	4

Y, years; M, male; F, female; NPD: Neuropsychiatric disorders; GDD: Global developmental delay; ID: Intellectual disability; ASD: Suspected/diagnostic autism spectrum disorders; ADHD: Suspected/diagnostic attention deficit hyperactivity disorder; MD: Motor disorders; Sleep: Sleep problems; Temper: Temper tantrums/socially inappropriate behavior