Table 2.

Univariate analysis to identify OS-related genes

Type	Genes	Occurrence (%)	HR(95%CI)	P-value
Mutation	NF1	22.2%	0.418 (0.141–1.238)	0.115
Mutation	KIT	16.7%	1.387 (0.548–3.513)	0.490
Mutation	BARD1	16.7%	1.217 (0.415–3.570)	0.721
Mutation	SPTA1	13.9%	0.565 (0.166–1.918)	0.360
Mutation	MGA	13.9%	1.619 (0.551–4.756)	0.381
Mutation	SF3B1	13.9%	1.510 (0.514–4.433)	0.453
Mutation	BCR	13.9%	0.565 (0.166–1.918)	0.360
Mutation	TP53	11.1%	1.971 (0.653–5.952)	0.229
Mutation	BRAF	11.1%	4.644 (1.495–14.425)	0.008
Mutation	GNAS	8.3%	1.570 (0.461–5.349)	0.471
Mutation	CTNNB1	8.3%	1.057 (0.246–4.535)	0.941
Mutation	SPEN	8.3%	0.518 (0.120–2.226)	0.376
Mutation	CDH1	8.3%	0.923 (0.271–3.138)	0.898
Mutation	PTPRT	8.3%	2.108 (0.618–7.195)	0.234
Mutation	NOTCH3	8.3%	0.266 (0.036–1.983)	0.196
Mutation	ERBB4	8.3%	0.604 (0.141–2.585)	0.496
Amplification	MYC	25.0%	1.168 (0.432–3.227)	0.764
Amplification	PDGFRA	22.2%	0.490 (0.146–1.648)	0.249
Amplification	CCND3	19.4%	0.693 (0.236–2.036)	0.505
Amplification	KIT	19.4%	0.688 (0.199–2.248)	0.515
Amplification	FGF6	16.7%	0.856 (0.290–2.523)	0.778
Amplification	FGF23	11.1%	1.005 (0.296–3.413)	0.994
Amplification	CCNE1	11.1%	1.046 (0.310–3.526)	0.942
Deletion	PTEN	16.7%	1.655 (0.655–4.183)	0.287
Deletion	NRG1	8.3%	16.478 (3.269–83.066)	0.001

RMM rectal mucosal melanoma, HR hazard ratio, CI confidence interval

Statistically significant P-values are bolded