Table 3.
Body mass index stratum specific time to event Hazard Ratios (HR) for the combined CKD event of CKD incidence, progression or End Stage Renal Disease in AKI group compared to non-AKI group including with interaction for body mass index
| Model 1 includes matching factors - age, CKD, diabetes, CVD, ICU, and urine albumin-to-creatinine ratio. | Model 2 Model 1 + race, sex, baseline eGFR, CHF, sepsis, and smoking | |||
|---|---|---|---|---|
| Events (n) | 300/1535 | 298/1521 | ||
| Overall | HR (95% CI) | p | HR (95% CI) | p |
| No AKI | 1.0 (ref) | – | 1.0 (ref) | – |
| AKI | 2.73 (2.12, 3.51) | < 0.001 | 2.43 (1.87, 3.16) | < 0.001 |
| BMI | HR (95% CI) | p | HR (95% CI) | p |
| ≤ 20 kg/m2 | 0.80 (0.14, 4.38) | 0.8 | 1.06 (0.19, 5.95) | 0.9 |
| 20–24.9 kg/m2 | 3.90 (1.93, 7.89) | < 0.001 | 4.04 (1.99, 8.22) | < 0.001 |
| 25–29.9 kg/m2 | 2.12 (1.37, 3.28) | 0.001 | 1.96 (1.26, 3.05) | 0.003 |
| ≥ 30 kg/m2 | 3.06 (2.15, 4.37) | < 0.001 | 2.51 (1.74, 3.61) | < 0.001 |
| p for interaction | 0.2 | 0.3 | ||
AKI acute kidney injury, BMI body mass index, CHF chronic heart failure, CI confidence interval, CKD chronic kidney disease, CVD cardiovascular disease, eGFR estimated glomerular filtration rate, ICU admission to intensive care unit
Note: urine albumin-to-creatinine ratio is log transformed; both models stratify by study center