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. 2021 May 28;7:19. doi: 10.1186/s40959-021-00106-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Heart failure adverse events in cancer therapy. a Forest plot represents matched logistic regression model results for heart failure in cancer treatment groups (anti-PD-(L)1, anti-CTLA4, combination (more than one ICI), and chemotherapy). Shown are significant adjusted p-value (q < .05) odds ratio and their 95% confidence interval. Red boxes represent an odds ratio greater than one, favoring immunotherapy. Blue boxes indicate an odds ratio less than one, favoring chemotherapy. b Incidence of heart failure by cancer histology is shown. Each color represents which treatment group the case corresponded to. Red corresponds to anti-CTLA4, green to anti-PD-(L)1, blue to chemotherapy, and purple to combination immunotherapy. Anti-CTLA4 = anti-cytotoxic T-lymphocyte-associated protein 4; ICI = immune checkpoint inhibitor; anti-PD-(L)1 = anti-programmed death protein 1 and anti-programmed death-ligand 1