Table 2.
Complete analysis of all cardiac AE risk from immunotherapy versus chemotherapy
| Adverse Event | Therapy | OR (95% CI) | q-value |
|---|---|---|---|
| Pericarditis | Combination v chemo | 0.61 (0.23, 1.67) | 0.339 |
| Combination v aCTLA4 | 1.79 (0.39, 8.3) | 0.457 | |
| Combination v aPD1L1 | 0.48 (0.24, 0.97) | 0.04 | |
| aPD1L1 v chemo | 1.28 (0.6, 2.72) | 0.523 | |
| aCTLA4 v chemo | 0.34 (0.07, 1.66) | 0.184 | |
| aCTLA4 v aPD1L1 | 0.27 (0.07, 1.1) | 0.068 | |
| Myocardial Infarction | Combination v chemo | 0.42 (0.29, 0.6) | < 0.001 |
| Combination v aPD1L1 | 0.94 (0.72, 1.24) | 0.671 | |
| Combination v aCTLA4 | 0.75 (0.5, 1.14) | 0.178 | |
| aPD1L1 v chemo | 0.44 (0.34, 0.58) | < 0.001 | |
| aCTLA4 v chemo | 0.56 (0.36, 0.85) | 0.007 | |
| aCTLA4 v aPD1L1 | 1.25 (0.87, 1.79) | 0.219 | |
| Heart Failure | Combination v chemo | 0.38 (0.27, 0.54) | < 0.001 |
| Combination v aPD1L1 | 0.84 (0.65, 1.08) | 0.171 | |
| Combination v aCTLA4 | 2.21 (1.22, 3.9) | < 0.001 | |
| aPD1L1 v chemo | 0.46 (0.36, 0.59) | < 0.001 | |
| aCTLA4 v chemo | 0.17 (0.1, 0.32) | < 0.001 | |
| aCTLA4 v aPD1L1 | 0.38 (0.22, 0.66) | < 0.001 | |
| Coronary Artery Disease | Combination v chemo | 0.64 (0.37, 1.12) | 0.12 |
| Combination v aCTLA4 | 1.47 (0.59, 3.63) | 0.405 | |
| Combination v aPD1L1 | 0.96 (0.6, 1.52) | 0.848 | |
| aPD1L1 v chemo | 0.67 (0.47, 0.96) | 0.028 | |
| aCTLA4 v chemo | 0.44 (0.18, 1.06) | 0.066 | |
| aCTLA4 v aPD1L1 | 0.65 (0.28, 1.49) | 0.309 | |
| Arrhythmias | Combination v CTLA4 | 0.92 (0.7, 1.23) | 0.584 |
| Combination v chemo | 0.71 (0.61, 0.84) | < 0.001 | |
| Combination v aPD1L1 | 1.06 (0.89, 1.26) | 0.531 | |
| aPD1L1 v chemo | 0.67 (0.61, 0.73) | < 0.001 | |
| aCTLA4 v chemo | 0.77 (0.61, 0.98) | 0.035 | |
| aCTLA4 v aPD1L1 | 1.15 (0.89, 1.47) | 0.289 | |
| Myocarditis | Combination v aPD1L1 | 1.41 (1.08, 1.85) | 0.012 |
| Combination v chemo | 30.76 (18.42, 51.37) | < 0.001 | |
| Combination v aCTLA4 | 3.93 (1.89, 8.16) | < 0.001 | |
| aPD1L1 v chemo | 21.81 (13.89, 34.24) | < 0.001 | |
| aCTLA4 v chemo | 7.83 (3.41, 18) | < 0.001 | |
| aCTLA4 v aPD1L1 | 0.36 (0.18, 0.73) | 0.005 |
Shown is the logistic regression model data of the entire dataset, cases are not matched; Combination indicates more than one immunotherapy was administered. Adjusted p-values (q-value) is displayed
aPD1L1 = anti- Programmed cell death protein - 1 and Programmed death ligand -1; aCTLA4 = cytotoxic T-lymphocyte- associated proteni 4