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. 2021 May 14;15:671249. doi: 10.3389/fnins.2021.671249

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Copyright © 2021 Gourain, Armant, Lübke, Diotel, Rastegar and Strähle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Injury-induced changes in levels of miRNAs. (A) The consistency of small RNASeq samples was tested by hierarchical clustering on Euclidean distances as for the RNASeq samples (see Figure 1A). The small RNASeq samples were consistently grouped into their respective condition, control or injured. (B) Changes in level of miRNAs were assessed comparing injured and uninjured telencephalic hemispheres. Significant differences in level of miRNA were tested (red; adjp < 0.05). (C) Targets of miR-182, miR155, miR-146a, and miR-31 were identified in the cholesterol synthesis pathway. For further details see also legend to Figures 3A, 4C.