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. Author manuscript; available in PMC: 2021 May 28.
Published in final edited form as: Hippocampus. 2019 Oct 17;30(5):435–455. doi: 10.1002/hipo.23163

TABLE 1.

Summary of hyperexcitability-induced changes in KCNQ2 transcription in the mouse hippocampus, as detected by KCNQ2 mRNA-EGFP reporter mice

Hippocampal subregion PILO (230 mg/kg) PILO (300 mg/kg) PTZ (60 mg/kg) CCI-TBI Composite response to hyperexcitability
CA1 pyramidal neurons Increase Decrease (cytotoxicity) Increase Increase (ipsilateral) Increase
CA3 pyramidal neurons Increase Decrease (cytotoxicity) Increase Increase (ipsilateral) Increase
DGGCs No significant change Increase No significant change Increase (ipsilateral) Context-dependent