Table 1.
Summary of included studies and patient demographics.
|
Study identification |
Study design | Application or electronic protocol name | Cause of hyperglycemia |
Total number of study participants |
Participant age, years | Insulin type | Total insulin dose (IU/kg/day) | Glycemic target (mg/dL) |
|---|---|---|---|---|---|---|---|---|
| Study #1: Schnipper32 |
Clinical Trial | Glycemic management protocol - Computer provider order entry (CPOE) | T2DM SH |
Pre-intervention: 63 Post-intervention: 106 |
Pre-intervention: 63 ± 15,7 Post-intervention: 64,7 ± 14,3 |
NPH, Glargine e Aspart |
0.5–0.7 | 60–180 |
| Study #2: Maynard37 |
Prospective Observational Study |
Structured subcutaneous insulin order sets and Insulin Management algorithm - Computer provider order entry (CPOE) | T2DM T1DM SH |
Pre-intervention: 2504 Post-intervention: 2295 |
Pre-intervention: 56 ± 17 Post-intervention: 56 ± 16 |
Glargine, Rapid-Acting and Short-Acting |
0.3–0.6 (according to BMI) | 60–180 |
| Study #3: Murphy38 |
Retrospective Observational Study |
Insulin protocol LUMC – Eletronic medical record (EMR) | T2DM T1DM SH |
No data | No available data | Glargine, NPH Lispro and Aspart |
0.2–0.8 (according to renal function, BMI and type of DM | 60–180 |
| Study #4: Wexler33 |
Clinical Trial | Computer order template for support basal-bolus insulin | Decompensated T2DM |
Intervention: 63 Control: 65 |
Intervention: 68 ± 14,3 Control: 70 ± 13,4 |
Glargine and Aspart | 0.5 | No data |
| Study #5: Schnipper34 |
Clinical Trial | Glycemic management protocol - Computer provider order entry (CPOE) | T2DM SH |
Intervention: 90 Control: 79 |
Intervention: 64,8 ± 15,5 Control: 65,4 ± 12,2 |
Glargine,NPH,Rapid-Acting and Short-Acting | 0.5–0.7 | 60–180 |
| Study #6: Neubauer35 |
Clinical Trial | GlucoTab | T2DM | 99 | 67 ± 11 | Glargine and Aspart | 0.5, but 0.3 if >70 years-old or Cr > 2 mg/dL | 70–140 |
| Study #7: Gregory36 |
Prospective Observational Study |
Comprehensive computadorized insulin order set and titration algorithm - Computer provider order entry (CPOE) | T2DM T2DM SH |
6526 | No available data | Glargine and Aspart | 0.1–0.3, according to age, type of DM, diet, BMI, renal function or history of pancreatectomy. | 70–180 |
T1DM1, Type 1 Diabetes mellitus; T2DM, Type 2 Diabetes mellitus; SH, stress hyperglycemia; BMI, body mass index; Cr, serum creatinine.