Table 3.
Univariate and multivariate cox regression analyses for overall survival in grade IV glioma.
| Variable | Complete dataset | 1:1 matched dataset | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||||||
| HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | |||||
| Age | 1.018 | (0.996- | 1.040) | 0.103 | 1.006 | 0.983 | 1.028 | 0.624 | 1.016 | 0.992 | 1.041 | 0.188 | 1.007 | 0.982 | 1.032 | 0.600 |
| Sex | ||||||||||||||||
| male vs. female | 1.152 | (0.624- | 2.128) | 0.65 | 1.183 | 0.584 | 2.396 | 0.640 | ||||||||
| No. of glioma | ||||||||||||||||
| multiple vs. single | 3.806 | (1.543- | 9.386) | 0.004* | 3.755 | 1.303 | 10.818 | 0.014* | 7.459 | 2.559 | 21.741 | <0.001* | 6.826 | 1.942 | 23.994 | 0.003* |
| Extent of resection | ||||||||||||||||
| GTR+NTR vs. STR+PR | 0.21 | 0.087 | 0.508 | 0.001* | 0.153 | 0.057 | 0.412 | <0.001* | 0.237 | 0.09 | 0.619 | 0.003* | 0.209 | 0.07 | 0.622 | 0.005 |
| IDH mutation | ||||||||||||||||
| yes vs. no | 0.518 | (0.260- | 1.033) | 0.062 | 0.631 | 0.271 | 1.466 | 0.284 | 0.372 | 0.14 | 0.984 | 0.046* | 0.38 | 0.127 | 1.132 | 0.082 |
| MGMT methylation | ||||||||||||||||
| positive vs. negative | 0.295 | (0.141- | 0.615) | 0.001* | 0.247 | 0.096 | 0.634 | 0.004* | 0.261 | 0.106 | 0.643 | 0.003* | 0.318 | 0.115 | 0.878 | 0.027* |
| ATRX mutation | ||||||||||||||||
| yes vs. no | 0.681 | (0.209- | 2.222) | 0.525 | 0.817 | 0.246 | 2.713 | 0.742 | ||||||||
| TP53 | ||||||||||||||||
| yes vs. no | 0.725 | (0.378- | 1.387) | 0.331 | 0.883 | 0.415 | 1.879 | 0.747 | ||||||||
| Ki-67 | 1.003 | (0.982- | 1.023) | 0.802 | 1.003 | 0.978 | 1.028 | 0.832 | ||||||||
| Epilepsy before surgery | ||||||||||||||||
| yes vs. no | 1.102 | (0.484- | 2.509) | 0.818 | 1.116 | 0.452 | 2.755 | 0.812 | ||||||||
| preoperative SIRI | ||||||||||||||||
| >1.26 vs. ≤1.26 | 1.661 | (0.878- | 3.141) | 0.119 | 3.963 | 1.833 | 8.565 | <0.001* | 1.843 | 0.895 | 3.797 | 0.097 | 3.204 | 1.391 | 7.379 | 0.006* |
| preoperative NLR | ||||||||||||||||
| >3.31 vs. ≤3.31 | 1.766 | (0.941- | 3.316) | 0.077 | 1.501 | 0.736 | 3.061 | 0.264 | ||||||||
| preoperative MLR | ||||||||||||||||
| >0.20 vs. ≤0.20 | 1.095 | (0.457- | 2.623) | 0.838 | 0.999 | 0.407 | 2.449 | 0.998 | ||||||||
| preoperative PLR | ||||||||||||||||
| >194 vs. ≤194 | 1.819 | (0.885- | 3.742) | 0.104 | 1.631 | 0.725 | 3.667 | 0.237 | ||||||||
CI, confidence interval; GTR, gross total resection; HR, hazard ratio; MLR, monocyte-lymphocyte ratio; NLR, neutrophil-lymphocyte ratio; No., number; NTR, near total resection; PLR, platelet-lymphocyte ratio; PR, partial resection; SIRI, systemic inflammatory response index; STR, subtotal resection. The bold values and the sign “*” meant: statistically significant (P < 0.05).