Table 4.
Univariate and multivariate cox regression analyses for overall survival in IDH wild-type IV glioma subgroup and IDH mutant-type IV glioma subgroup.
| Variable | IDH wild-type IV glioma subgroup | IDH mutant-type IV glioma subgroup | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||||||
| HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | |||||
| Age | 1.007 | (0.984- | 1.030) | 0.565 | 1.001 | 0.974 | 1.028 | 0.962 | 1.042 | (0.994- | 1.093) | 0.086 | 1.029 | 0.975 | 1.085 | 0.297 |
| Sex | ||||||||||||||||
| male vs. female | 1.132 | (0.540- | 2.375) | 0.742 | 0.787 | (0.235- | 2.634) | 0.698 | ||||||||
| No. of glioma | ||||||||||||||||
| multiple vs. single | 2.669 | (0.996- | 7.153) | 0.051 | 3.227 | 1.011 | 10.301 | 0.048* | 24.486 | (1.498- | 400.306) | 0.025 | 3.064 | 0.109 | 85.748 | 0.510 |
| Extent of resection | ||||||||||||||||
| GTR+NTR vs. STR+PR | 0.265 | 0.097 | 0.719 | 0.009* | 0.176 | 0.058 | 0.533 | 0.002* | 0.059 | 0.005 | 0.702 | 0.025* | 0.047 | 0.001 | 1.585 | 0.088 |
| MGMT methylation | ||||||||||||||||
| positive vs. negative | 0.402 | (0.136- | 1.183) | 0.098 | 0.36 | 0.11 | 1.174 | 0.090 | 0.133 | (0.023- | 0.750) | 0.022* | 0.115 | 0.017 | 0.784 | 0.027* |
| ATRX mutation | ||||||||||||||||
| yes vs. no | 0.471 | (0.142- | 1.563) | 0.219 | NA | |||||||||||
| TP53 | ||||||||||||||||
| yes vs. no | 1.117 | (0.531- | 2.354) | 0.770 | 0.101 | (0.014- | 0.726) | 0.023* | ||||||||
| Ki-67 | 0.996 | (0.974- | 1.020) | 0.762 | 1.018 | (0.977- | 1.062) | 0.391 | ||||||||
| Epilepsy before surgery | ||||||||||||||||
| yes vs. no | 2.644 | (1.030- | 6.785) | 0.043* | 1.981 | 0.719 | 5.453 | 0.186 | 0.205 | (0.025- | 1.665) | 0.138 | ||||
| preoperative SIRI | ||||||||||||||||
| >1.26 vs. ≤1.26 | 2.158 | (1.004- | 4.639) | 0.049* | 2.814 | 1.174 | 6.747 | 0.020* | 2.128 | (0.464- | 9.752) | 0.331 | 13.234 | 0.803 | 218.042 | 0.071 |
| preoperative NLR | ||||||||||||||||
| >3.31 vs. ≤3.31 | 1.953 | (0.918- | 4.155) | 0.082 | 2.276 | (0.640- | 8.091) | 0.204 | ||||||||
| preoperative MLR | ||||||||||||||||
| >0.20 vs. ≤0.20 | 1.078 | (0.410- | 2.834) | 0.879 | 1.414 | (0.177- | 11.288) | 0.744 | ||||||||
| preoperative PLR | ||||||||||||||||
| >194 vs. ≤194 | 2.097 | (0.842- | 5.219) | 0.112 | 2.247 | (0.632- | 7.995) | 0.211 | ||||||||
CI, confidence interval; GTR, gross total resection; HR, hazard ratio; MLR, monocyte-lymphocyte ratio; NA, not applicable; NLR, neutrophil-lymphocyte ratio; No., number; NTR, near total resection; PLR, platelet-lymphocyte ratio; PR, partial resection; SIRI, systemic inflammatory response index; STR, subtotal resection. The bold values and the sign “*” meant: statistically significant (P < 0.05).