Table 5.
Univariate and multivariate cox regression analyses for overall survival in grade III glioma.
| Variable | Complete dataset | 1:1 matched dataset | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||||||
| HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | |||||
| Age | 1.077 | (1.020- | 1.137) | 0.007* | 1.177 | 1.072 | 1.292 | 0.001* | 1.037 | 0.966 | 1.113 | 0.315 | 1.162 | 1.036 | 1.303 | 0.010* |
| Sex | ||||||||||||||||
| male vs. female | 1.042 | (0.348- | 3.119) | 0.942 | 0.832 | 0.222 | 3.119 | 0.785 | ||||||||
| Histology | ||||||||||||||||
| AO vs. AA | 0.659 | 0.203 | 2.146 | 0.489 | 0.065 | 0.008 | 0.545 | 0.012* | 0.202 | 0.025 | 1.62 | 0.132 | 0.082 | 0.007 | 0.893 | 0.040* |
| NOS vs. AA | 1.209 | 0.151 | 9.698 | 0.859 | 0.013 | 0 | 3.256 | 0.123 | NA | |||||||
| No. of glioma | ||||||||||||||||
| multiple vs. single | 6.283 | (1.328- | 29.73) | 0.020* | 2.432 | 0.181 | 32.743 | 0.503 | 25.456 | 1.59 | 407.465 | 0.022* | 15.044 | 0.268 | 845.737 | 0.187 |
| Extent of resection | ||||||||||||||||
| GTR+NTR vs. STR+PR | 0.284 | 0.093 | 0.871 | 0.028* | 0.085 | 0.011 | 0.649 | 0.018* | 0.214 | 0.053 | 0.862 | 0.030* | 0.079 | 0.009 | 0.678 | 0.021* |
| IDH mutation | ||||||||||||||||
| yes vs. no | 2.248 | 0.293 | 17.221 | 0.436 | 0.452 | 0.036 | 5.691 | 0.539 | 24.962 | 0.004 | 158584.761 | 0.471 | ||||
| MGMT methylation | ||||||||||||||||
| positive vs. negative | 0.516 | (0.176- | 1.517) | 0.229 | 0.022 | 0.002 | 0.308 | 0.005* | 0.665 | 0.176 | 2.513 | 0.548 | 0.08 | 0.007 | 0.929 | 0.044* |
| 1p19q deletion | ||||||||||||||||
| yes vs. no | 0.648 | (0.203- | 2.074) | 0.465 | 0.202 | 0.025 | 1.62 | 0.132 | ||||||||
| ATRX mutation | ||||||||||||||||
| yes vs. no | 1.484 | (0.512- | 4.298) | 0.467 | 7.132 | 0.888 | 57.285 | 0.065 | ||||||||
| TP53 | ||||||||||||||||
| yes vs. no | 0.51 | (0.111- | 2.333) | 0.385 | 23.16 | 0 | 3.95091E+11 | 0.794 | ||||||||
| Ki-67 | 1.038 | (1.002- | 1.075) | 0.036* | 1.049 | 0.964 | 1.141 | 0.264 | 1.031 | 0.98 | 1.086 | 0.238 | ||||
| Epilepsy before surgery | ||||||||||||||||
| yes vs. no | 0.317 | (0.088- | 1.147) | 0.08 | 0.276 | 0.049 | 1.564 | 0.146 | 0.374 | 0.092 | 1.512 | 0.168 | ||||
| preoperative SIRI | ||||||||||||||||
| >1.26 vs. ≤1.26 | 2.935 | (1.009- | 8.540) | 0.048* | 36.973 | 3.411 | 400.783 | 0.003* | 3.981 | 0.968 | 16.371 | 0.055 | 12.043 | 1.381 | 104.989 | 0.024* |
| preoperative NLR | ||||||||||||||||
| >3.31 vs. ≤3.31 | 3.11 | (1.082- | 8.938) | 0.035* | 3.735 | 0.997 | 13.994 | 0.051 | ||||||||
| preoperative MLR | ||||||||||||||||
| >0.20 vs. ≤0.20 | 2.456 | (0.759- | 7.944) | 0.134 | 3.773 | 0.772 | 18.439 | 0.101 | ||||||||
| preoperative PLR | ||||||||||||||||
| >194 vs. ≤194 | 2.654 | (0.582- | 12.100) | 0.207 | 11.505 | 1.037 | 127.618 | 0.047* | ||||||||
AA, anaplastic astrocytomas; AO, anaplastic oligodendrogliomas; CI, confidence interval; GTR, gross total resection; HR, hazard ratio; MLR, monocyte-lymphocyte ratio; NA, not applicable; NLR, neutrophil-lymphocyte ratio; No., number; NOS, not otherwised speccified; NTR, near total resection; PLR, platelet-lymphocyte ratio; PR, partial resection; SIRI, systemic inflammatory response index; STR, subtotal resection. The bold values and the sign “*” meant: statistically significant (P < 0.05).