Table 6.

Univariate and multivariate cox regression analyses for overall survival in IDH mutant-type grade III glioma subgroup.

Variable	Univariate analysis				Multivariate analysis
	HR	(95% CI)		p value	HR	(95% CI)		p value
Age	1.067	(1.010-1.127)		0.020*	1.147	1.058	1.244	0.001*
Sex
male vs. female	1.355	(0.442-4.155)		0.596
Histology
AO vs. AA	0.552	0.166 1.839		0.333	0.153	0.031	0.747	0.020*
NOS vs. AA	0.987	0.1218.042		0.990	0.258	0.014	4.851	0.366
No. of glioma
multiple vs. single	5.735	(1.185-27.766)		0.030*	7.732	0.686	87.216	0.098
Extent of resection
GTR+NTR vs. STR+PR	0.283	0.089 0.898		0.032*	0.152	0.025	0.914	0.040*
MGMT methylation
positive vs. negative	0.503	(0.165-1.530)		0.226	0.042	0.005	0.364	0.004*
1p19q deletion
yes vs. no	0.652	(0.200- 2.123)		0.478
ATRX mutation
yes vs. no	1.651	(0.538- 5.059)		0.381
TP53
yes vs. no	0.563	(0.123-2.572)		0.458
Ki-67	1.037	(1.000-1.075)		0.050
Epilepsy before surgery
yes vs. no	0.326	(0.089-1.198)		0.091
preoperative SIRI
>1.26 vs. ≤1.26	3.711	(1.191-11.565)		0.024*	24.479	3.647	164.311	0.001*
preoperative NLR
>3.31 vs. ≤3.31	3.534	(1.183-10.561)		0.024*
preoperative MLR
>0.20 vs. ≤0.20	2.847	(0.765-10.594)		0.119
preoperative PLR
>194 vs. ≤194	2.217	(0.482-10.196)		0.306

AA, anaplastic astrocytomas; AO, anaplastic oligodendrogliomas; CI, confidence interval; GTR, gross total resection; HR, hazard ratio; MLR, monocyte-lymphocyte ratio; NLR, neutrophil-lymphocyte ratio; No., number; NOS, not otherwised speccified; NTR, near total resection; PLR, platelet-lymphocyte ratio; PR, partial resection; SIRI, systemic inflammatory response index; STR, subtotal resection. The bold values and the sign “*” meant: statistically significant (P < 0.05).