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. 2021 May 14;11:548243. doi: 10.3389/fonc.2021.548243

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Copyright © 2021 Ghantasala, Pai, Biswas, Gahoi, Mukherjee, KP, Nissa, Srivastava, Epari, Shetty, Moiyadi and Srivastava

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MRM analysis of Glioma CSF and tissue samples. (A) T1 contrast images showing Low Grade Glioma and High Grade Glioma, respectively; (B) Representative peak shape for AATVGSLAGQPLQER and bar plots of AATVGSLAGQPLQER, LGPLVEQGR and SELEEQLTPVAEETR, respectively showing overexpression of APOE in CSF samples of GBM (n=5) as compared to LGG (n=5); (C) Representative peak shape for LLDNWDSVTSTFSK and bar plots of LLDNWDSVTSTFSK, DYVSQFEGSALGK and ATEHLSTLSEK, respectively showing overexpression of APOA1 in GBM CSF samples as compared to LGG CSF samples; (D) Representative MRM peak for one peptide of SOD2 and bar plots depicting the increased expression of peptides GDVTAQIALQPALK, LLDNWDSVTSTFSK and ATEHLSTLSEK of SOD2 in Glioma tumor tissue samples (n=6) as compared to peritumoral controls (n=3).