FIGURE 3.

Antithrombotic effects in the NHP model of electrolytically mediated carotid arterial thrombosis. Effects of vehicle, BMS‐724296, apixaban, and dabigatran on carotid blood flow after thrombus induction in the injured carotid artery. Carotid blood flow was expressed as a percentage of control carotid blood flow. Vehicle (n = 8); BMS‐724296 at 0.025 + 0.05 (LD; n = 5), 0.05 + 0.1 (MD1; n = 6), 0.102 + 0.2 (MD2; n = 6), and 0.4 + 0.8 (HD; n = 6) mg/kg+mg/kg/h i.v.; apixaban at 0.024 + 0.036 (LD; n = 4), 0.12 + 0.18 (MD; n = 4), and 0.6 + 0.9 (HD; n = 4) mg/kg+mg/kg/h i.v.; and dabigatran at 0.024 + 0.036 (LD; n = 3), 0.12 + 0.18 (MD; n = 3), and 0.6 + 0.9 (HD; n = 3) mg/kg+mg/kg/h i.v. Data are mean ± SEM. HD, high dose; i.v., intravenous; LD, low dose; MD, medium dose; NHP, nonhuman primate; SEM, standard error of the mean