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. 2021 May 28;5(4):e12524. doi: 10.1002/rth2.12524

FIGURE 6.

FIGURE 6

Effects of vehicle, BMS‐724296, apixaban, and dabigatran on clotting times (top panel: aPTT; middle panel: PT; bottom panel: TT) in NHPs. Vehicle (n = 8); BMS‐724296 at 0.025 + 0.05 (LD; n = 5), 0.05 + 0.1 (MD1; n = 6), 0.102 + 0.2 (MD2; n = 6), and 0.4 + 0.8 (HD; n = 6) mg/kg+mg/kg/h i.v.; apixaban at 0.024 + 0.036 (LD; n = 4), 0.12 + 0.18 (MD; n = 4), and 0.6 + 0.9 (HD; n = 4) mg/kg+mg/kg/h i.v.; and dabigatran at 0.024 + 0.036 (LD; n = 3), 0.12 + 0.18 (MD; n = 3), and 0.6 + 0.9 (HD; n = 3) mg/kg+mg/kg/h i.v. Data are mean ± SEM. *P < .05 compared to vehicle. aPTT, activated partial thromboplastin time; HD, high dose; i.v., intravenous; LD, low dose; MD, medium dose; NHP, nonhuman primate; PT, prothrombin time; TT, thrombin time; SEM, standard error of the mean