Table 1.
Clinicopathological characteristics of patients with MSH2-deficient CRC.
| LS | Inconclusive dMSH2 | x2/t | P-value | ||||
|---|---|---|---|---|---|---|---|
| n = 45 | n = 24 | ||||||
| No. | Percent | No. | Percent | ||||
| Age at diagnosis (years) | |||||||
| Mean (SD) | 48.3 (11.3) | 53.3 (14.9) | – | 0.120 | |||
| ≤70 | 45 | 100.0% | 20 | 83.3% | - | 0.012 | |
| >70 | 0.0% | 4 | 16.7% | ||||
| Gender | 3.757 | 0.053 | |||||
| Male | 33 | 73.3% | 12 | 50.0% | |||
| Female | 12 | 26.7% | 12 | 50.0% | |||
| Tumor location | 3.202 | 0.362 | |||||
| Proximal colon | 20 | 44.4% | 13 | 54.2% | |||
| Distal colon | 9 | 20.0% | 4 | 16.7% | |||
| Rectum | 11 | 24.4% | 7 | 29.2% | |||
| Othera | 5 | 11.1% | 0.0% | ||||
| Tumor stage | 3.326 | 0.505 | |||||
| I | 9 | 20.0% | 4 | 16.7% | |||
| II | 20 | 44.4% | 12 | 50.0% | |||
| III | 8 | 17.8% | 6 | 25.0% | |||
| IV | 5 | 11.1% | 0.0% | ||||
| NA | 3 | 6.7% | 2 | 8.3% | |||
| Histological type | 0.594 | 0.743 | |||||
| Adenocarcinoma | 41 | 91.1% | 22 | 91.7% | |||
| Mucinous adenocarcinoma | 3 | 6.7% | 2 | 8.3% | |||
| Otherb | 1 | 2.2% | 0.0% | ||||
| Personal history of cancers | 5.269 | 0.022 | |||||
| Yes | 15 | 33.3% | 2 | 8.3% | |||
| No | 30 | 66.7% | 22 | 91.7% | |||
| Family history of LSRC | 11.829 | 0.003 | |||||
| Yes | 30 | 66.7% | 6 | 25.0% | |||
| No | 15 | 33.3% | 17 | 70.8% | |||
| Unknown | 0.0% | 1 | 4.2% | ||||
| Revised Bethesda guidelines | 2.406 | 0.121 | |||||
| Met | 40 | 88.9% | 17 | 70.8% | |||
| Not met | 5 | 11.1% | 7 | 29.2% | |||
| Not available | |||||||
| Amsterdam II criteria | 7.134 | 0.028 | |||||
| Met | 9 | 20.0% | 0.0% | ||||
| Not met | 36 | 80.0% | 23 | 95.8% | |||
| Not available | 0.0% | 1 | 4.2% | ||||
dMSH2, deficient MSH2; LSRC, Lynch syndrome-related cancers; SD, standard deviation.
a. Ungrouped data, including 5 patients with 4 CRC tumors located in two sites among the proximal colon, distal colon or rectum, and 1 colon tumor with an unspecified location.
b. Indicates two synchronous cancers at the sigmoid colon and splenic flexure with mucinous carcinoma and adenocarcinoma histologic types, respectively.