TABLE 3.
Patient Outcomes
| Outcomes | Early Intubation Cohort (n = 30) | Late Intubation Cohort (n = 24) | p |
|---|---|---|---|
| ICU course | |||
| Vasopressor >4 hr | 18 (60%) | 20 (83%) | 0.02a |
| Prone positioning | 13 (43%) | 11 (46%) | 0.8 |
| Neuromuscular blockade | 12 (40%) | 6 (25%) | 0.13 |
| Inhaled nitric oxide | 1 (3%) | 2 (8%) | 0.17 |
| New renal replacement therapy | 3 (10%) | 7 (29%) | 0.07 |
| Extracorporeal membrane oxygenation | 5 (17%) | 1 (4%) | 0.1 |
| Tracheostomy | 6 (20%) | 5 (21%) | 0.92 |
| Respiratory and ventilator mechanics | |||
| Pao2/Fio2 ratio at intubation | 184 (114–245) | 186 (116–235) | 0.93 |
| Compliance at intubation | 31 (27–53) | 33 (27–35) | 0.53 |
| Driving pressure at intubation | 12 (8.5–15) | 13 (10–17) | 0.25 |
| Dead space fraction | 0.40 (0.35–0.52) | 0.52 (0.40–0.59) | 0.03a |
| Ventilatory ratio | 1.42 (1.15–1.65) | 1.64 (1.55–2.03) | 0.4 |
| Positive end-expiratory pressure at time of intubation | 10 (10–14) | 10 (10–12) | 0.53 |
| Hospital course | |||
| Hospital length of stay | 19 (10–28) | 29 (19–33) | 0.04a |
| ICU length of stay | 12 (5–17) | 15 (10–19) | 0.13 |
| Duration of mechanical ventilation | 10 (5–15) | 10 (7–19) | 0.36 |
| Disposition | |||
| Home | 18 (60%) | 7 (29%) | 0.14 |
| Acute inpatient rehabilitation | 5 (16%) | 3 (13%) | |
| Skilled nursing | 2 (6%) | 4 (17%) | |
| Long-term acute care | 3 (10%) | 3 (13%) | |
| Mortality | 2 (6%) | 7 (29%) | <0.001a |
ap < 0.05.
All values are reported as n (%) or median (interquartile range).