TABLE 5.
Risk Factors for 30-d Mortality of ICU Cornavirus Disease 2019 Patients During the First and second Waves of the Cornavirus Disease 2019 pandemic
| Variables | n | Univariate | Multivariate (n = 199) | ||
|---|---|---|---|---|---|
| HR (95% CI) | pa | HR (95% CI) | p | ||
| Wave (s) | 215 | 1.03 (0.61–1.75) | 0.91 | 0.68 (0.37–1.24) | 0.21 |
| Age (yr) | 215 | 1.06 (1.03–1.10) | 0.0001 | 1.06 (1.03–1.10) | 0.0004 |
| Body mass index (kg/m2) | 197 | 0.99 (0.95–1.05) | 0.97 | ||
| Gender (male) | 215 | 1.37 (0.73–2.55) | 0.33 | ||
| Chronic kidney disease (yes) | 215 | 1.80 (1.03–3.16) | 0.040 | ||
| Diabetes (yes) | 215 | 0.79 (0.46–1.33) | 0.37 | ||
| Hypertension (yes) | 215 | 1.03 (0.59–1.80) | 0.91 | ||
| Sequential Organ Failure Assessment on ICU admission | 205 | 1.13 (1.05–1.21) | 0.0007 | 1.13 (1.03–1.25) | 0.0083 |
| Pao2/Fio2 on ICU admission (mm Hg, Ln) | 133 | 0.64 (0.27–1.53) | 0.32 | ||
| Mean arterial pressure on ICU admission (mm Hg) | 215 | 0.96 (0.94–0.98) | 0.0007 | ||
| Lymphocytes on ICU admission (103/mm3, Ln) | 212 | 0.57 (0.40–0.83) | 0.0033 | 0.57 (0.38–0.85) | 0.0057 |
| C-reactive protein on ICU admission (mg/L) | 213 | 1.00 (0.99–1.003) | 0.73 | ||
| d-dimers on ICU admission (µg/L, Ln) | 185 | 1.05 (0.80–1.37) | 0.73 | ||
| Creatinine on ICU admission (mg/dL, Ln) | 213 | 1.40 (0.96–2.04) | 0.085 | ||
| Total bilirubin on ICU admission (mg/dL, Ln) | 212 | 0.90 (0.58–1.42) | 0.66 | ||
| Platelet count on ICU admission (103/mm3, Ln) | 213 | 0.60 (0.36–1.004) | 0.052 | ||
| Ferritin on ICU admission (µg/L, Ln) | 123 | 1.12 (0.82–1.55) | 0.47 | ||
| Troponin on ICU admission (ng/L, Ln) | 209 | 1.26 (1.12–1.43) | 0.0003 | ||
HR = hazard ratio, Ln = Neperian logarithm.
Cox regression models are used to assess risk factors of mortality. All the variables with p < 0.1 were selected for the multivariate model.
aAdjusted for wave.