TABLE 2.

Pathophysiological classification of generalized peripheral nerve hyperexcitability syndromes

Classification	Mechanism
Hereditary channelopathies	VGKC mutation
Immune‐mediated channelopathies	VGKC‐complex antibodies
Paraneoplastic causes	VGKC‐complex antibodies
Polyneuropathies	Demyelination leading to paranodal reorganization of VGKC and VGKC‐complex proteins
Motor neuron disease	Ion channel dysfunction via various mechanisms
Neurodegenerative disease	VGKC dysfunction
Metabolic disease	Prolonged depolarization of the action potential relating to electrolyte disturbance or endocrinopathy
Benign causes	Stress, exercise
Toxicities	Stress, exercise

Abbreviation: VGKC, voltage‐gated potassium channel.