Table 3.
Hazard Ratio of Incident Cataract Surgery Across Different Alcohol Beverages among Drinkers Compared with Nondrinkers in EPIC-Norfolk
|
Amount of Alcohol Intake (g) |
No. of Incident Cases | No. at Risk | Univariable Model |
Multivariable Model |
||
|---|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |||
| Nondrinkers | 1118 | 4516 | Ref | Ref | ||
| Wine drinkers | ||||||
| First tertile | 1626 | 7902 | 0.76 (0.70–0.82) | <0.001 | 0.98 (0.91–1.06) | 0.57 |
| Second tertile | 688 | 4169 | 0.58 (0.53–0.64) | <0.001 | 0.81 (0.74–0.89) | <0.001 |
| Third tertile | 547 | 3721 | 0.52 (0.47–0.58) | <0.001 | 0.77 (0.69–0.85) | <0.001 |
| P for trend | <0.001 | <0.001 | ||||
| Nondrinkers | 1118 | 4516 | Ref | Ref | ||
| Beer drinkers | ||||||
| First tertile | 985 | 5532 | 0.65 (0.59–0.71) | <0.001 | 0.92 (0.84–1.01) | 0.07 |
| Second tertile | 392 | 2524 | 0.56 (0.50–0.63) | <0.001 | 0.87 (0.77–0.99) | 0.033 |
| Third tertile | 360 | 2567 | 0.52 (0.46–0.59) | <0.001 | 0.91 (0.80–1.04) | 0.18 |
| P for trend | <0.001 | 0.07 | ||||
| Nondrinkers | 1118 | 4516 | Ref | Ref | ||
| Spirits drinkers | ||||||
| First tertile | 642 | 3591 | 0.64 (0.58–0.71) | <0.001 | 0.94 (0.85–1.04) | 0.23 |
| Second tertile | 815 | 4524 | 0.66 (0.61–0.72) | <0.001 | 0.91 (0.83–1.00) | 0.06 |
| Third tertile | 356 | 1842 | 0.76 (0.68–0.86) | <0.001 | 0.86 (0.76–0.97) | 0.016 |
| P for trend | <0.001 | 0.009 | ||||
BMI = body mass index; CI = confidence interval; EPIC = European Prospective Investigation of Cancer.
Multivariable model adjusted for age, sex, ethnicity, Townsend deprivation index, BMI, smoking, and diabetes status.
Bold values denote statistical significance at the P < 0.05 level.