Table 2.

Dose levels with number of patients, dose delays, dose reductions and dose limiting toxicities (DLTs)

Dose level	AR-42 dose (mg)	No. of patients enrolled (N=17)	No. of dose delays	No. of dose reductions	No. of patients with a DLT	Description of DLT
1A	30	3	0	0	0	---
2A	60	2a	0	0	0	---
1B	60	7b	4	2	1	Thrombocytopenia (grade 3)
2B	80	2c	0	0	1	Thrombocytopenia (grade 3)d Psychiatric disorder (grade 4)d
Expansion cohort	60	3	0	0	---

^aGrade 2 thrombocytopenia experienced by second patient, so advanced to stage B.

^bIncludes 2 cohorts of 3 patients, plus one patient to replace a patient who was non-compliant and not evaluable.

^cFirst patient withdrew after 2 doses due to progression and was replaced. Second patient experienced a DLT.

^dGrade 3 thrombocytopenia and grade 4 psychiatric disorder at dose level 2B occurred in the same patient, counting as one DLT.