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. Author manuscript; available in PMC: 2021 May 28.
Published in final edited form as: J Control Release. 2020 Oct 10;329:762–773. doi: 10.1016/j.jconrel.2020.10.010

Fig. 2.

Fig. 2.

In vitro studies. A, B) Cumulative release of EPO-R76E from the PPS (A) and PLGA (B) MPs into solution over time showing mean ± s.d. C) Quantification of cell viability after exposure to different amounts of empty and loaded MPs showing mean ± s.d. D) Quantification of H2O2 induced ARPE-19 cell death. Cells challenged with cytotoxic levels of H2O2 were treated with PPS, PPS + EPO-R76E, PLGA, or PLGA+EPO-R76E MPs. E, F) Quantification of DHE fluorescence in ARPE-19 cells treated with empty or EPO-R76E loaded PPS (E) or PLGA (F) MPs. For the cell survival and DHE experiments, cells were treated with the appropriate quantity of MPs to provide a 50 ng EPO-R76E dose.