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Self-administered nicotine significantly suppressed body weight gain (a), and fat mass, but not lean mass, gain (b). Nicotine reduced the percentage of fat mass (c) but not lean mass (d) compared to saline, over 14 days of self-administration. Infusions earned in 1-h daily sessions is graphed as an inset in panel a. The asterisk indicates p < 0.05 between drug groups
