Table 1.

Clinical features reported in association with hereditary alpha-tryptasemia (HαT).

Manifestation	Reported Prevalence*	Association Supported in an Unselected Cohort‡
Basal serum tryptase >8ng/mL	100%	Yes
Chronic gastroesophageal reflux symptoms	56-77%	No
Arthralgia	44-45%	No
Body pain/Headache	33-47%	No
Flushing/Pruritus	32-55%	Yes
Irritable bowel syndrome (Rome III)	28-49%	Yes
Sleep disruption	22-39%	No
Systemic immediate hypersensitivity reaction	21-28%	No
Retained primary dentition	20-33%	Yes
Systemic venom reaction	14-22%	Yes
Congenital skeletal abnormality	11-26%	No
Joint Hypermobility	0-28%	No
Positive Tilt-table test	0-11%	No

^*in order of reported prevalence, ranges are derived from available data in three reports (27) (26) (26, 65)

^‡finding was identified as significantly associated with increased TPSAB1 copy number in an unselected volunteer adult population.