Cortical bone is increased by MFN2 deficiency in the osteoblast lineage in growing females. A,B) MicroCT analysis shows that cortical thickness (Ct.Th, A), but not trabecular bone volume fraction (BV/TV, B) in the distal femur is increased at 8 weeks of age. Representative images shown with scale bars = 400 μm. C,D) Serum markers of bone turnover, P1NP (C) and CTX-1 (D), remain unchanged at this age. Unpaired t-tests shown, n=10.