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Endocortical bone formation is increased in MFN2 cKO females. A) Representative images of alizarin red and calcein green labels along endocortical surface in 18 week old females. Scale bar = 100 μm. Dynamic histomorphometry along the endocortical surface in 18 week old female WT and cKO mice shows no change in mineral apposition rate (MAR, B), while mineralizing surface (MS/BS, C) and bone formation rate (BFR/BS, D) are increased. Unpaired t-tests with Welch’s correction, n=12-13.
