Figure 2:

Features of standard eQTLs are inconsistent with roles in disease. (a) Truly deleterious alleles (red) are unlikely to affect many tissues without encountering strong selective pressures, limiting their persistence in the population. Alleles wide effects are more likely benign (purple). (b) Standard eQTL genes (blue) are shared across primates. These genes show lower levels of sequence conservation, indicating a less sensitive role in physiology.