Table 2.

Psychosocial model

	Cognitive impairment (using MoCA)				Realtive cognitive impairment
	OR (95% CI)				OR (95% CI)
Variable	Unadjusted	Model 1	Model 2	Model 3	Unadjusted	Model 1	Model 2	Model 3
eGFR (per mL/min /1.73 m2 increase)	0.984 (0.970–0.999)*	0.988 (0.973–1.003)	0.988 (0973–1.003)	0.991 (0.973–1.008)	0.969 (0.950-0.988)*	0.976 (0.956–0.997)*	0.976 (0.956–0.997)*	0.982 (0.959–1.006)
Age (per year)	1.037 (1.017–1.057)*	X	1.035 (1.015–1.055)*	1.045 (1.018–1.072)*	1.095 (1.062–1.130)*		1.088 (1.055–1.122)*	1.097 (1.055–1.140)*
Male sex	1.089 (0.643–1.843)	1.060 (0.616–1.824)	1.098 (0.635–1.901)	1.100 (0.571–2.119)	0.855 (0.470–1.554)	0.785 (0.404–1.527)	0.875 (0.444–1.725)	0.687 (0.313–1.509)
Living alone	1.467 (0.772–2.787)	0.798 (0.412–1.546)	1.232 (0.634–2.394)	1.497 (0.696–3.222)	1.246 (0.608–2.554)	0.908 (0.412–1.998)	0.878 (0396–1.947)	1.118 (0.456–2.745)
Raised BMI	0.643 (0.341–1.210)	0.546 (0.281–1.063)	0.559 (0.287–1.090)	0.486 (0.226–1.046)	1.717 (0.778–3.791)	1.600 (0.670–3.823)	1.654 (0.688–3.980)	1.980 (0.704–5.573)
Smoking history	1.228 (0.745–2.025)	1.127 (0.672–1.889)	1.083 (0.643–1.825)	0.856 (0.461–1.588)	1.114 (0.627–1.980)	0.857 (0.451–1.629)	0.835 (0.435–1.600)	0.833 (0.395–1.757)
Alcohol excess	0.954 (0.460–1.977)	0.959 (0.445–2.022)	0.945 (0.446–2.004)	0.993 (0.406–2.431)	1.51 (0.621–3.701)	1.163 (0.411–3.294)	1.470 (0.593–3.647)	1.978 (0.694–5.635)
≤12-year education	1.095 (0.664–1.805)	0.804 (0.469–1.379)	0.770 (0.446–1.329)	0.742 (0.386–1.429)	1.583 (0.882–2.844)	0.933 (0.483–1.803)	0.874 (0.447–1.710)	0.772 (0.351–1.696)
Anxiety or depression	2.676 (1.172–6.112)*	3.536 (1.463–8.548)*	3.425 (1.408–8.332)*	4.325 (1.694–11.044)*	3.180 (0.767–13.181)	6.801 (1.248–37.068)*	5.049 (0.918–27.784)	4.921 (0.827–29.266)

^*P ≤ 0.05. Model 1 is adjusted for age, Model 2 is adjusted for age and eGFR and Model 3 is adjusted for all variables listed.