Table 4.
Logistic regression adjusted for age and eGFR split by known vascular disease
| Cognitive impairment [n = 56/156 (35.9%)] |
Relative cognitive impairment [n = 29/156 (18.6%)] |
Cognitive impairment [n = 55/94 (58.5%)] |
Relative cognitive impairment [n = 33/94 (35.1%)] |
|||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| No vascular disease, n = 156 | Vascular disease, n = 94 | |||||||
| Male | 1.591 (0.758–3.341) | 0.220 | 0.942 (0.66–2.425) | 0.901 | 0.675 (0.278–1.639) | 0.385 | 0.759 (0.282–2.045) | 0.759 |
| BMI >25 | 0.780 (0.343–1.776) | 0.555 | 1.467 (0.453–4.754) | 0.523 | 0.175 (0.040–0.773) | 0.021 | 1.804 (0.477–6.825) | 0.385 |
| Living alone | 1.541 (0.622–3.821) | 0.350 | 0.963 (0.295–3.139) | 0.963 | 0.962 (0.354–2.616) | 0.940 | 0.857 (0.286–2.568) | 0.783 |
| >14 units of alcohol per week | 1.323 (0.512–3.416) | 0.563 | 1.333 (0.371–4.790) | 0.660 | 0.523 (0.148–1.851) | 0.315 | 1.500 (0.395–5.687) | 0.551 |
| Smoking history | 0.943 (0.478–1.861) | 0.866 | 0.630 (0.252–1.575) | 0.324 | 1.089 (0.456–2.602) | 0.848 | 1.086 (0.407–2.893) | 0.869 |
| Psychodynamic medications | 5.139 (1.318–20.038) | 0.018 | 7.994 (1.573–40.634) | 0.012 | 0.904 (0.313–2.620) | 0.853 | 1.405 (0.426–4.631) | 0.577 |
| Depression | 4.117 (1.088–15.581) | 0.037 | 5.122 (0.586–44.71) | 0.140 | 2.304 (0.692–7.671) | 0.174 | 5.510 (0.380–79.787) | 0.211 |
| Education ≤12 years | 0.344–1.437 | 0.344 | 1.311 (0.511–3.365) | 0.574 | 0.880 (0.365–2.121) | 0.776 | 0.589 (0.221–1.569) | 0.290 |
| Comorbidities | ||||||||
| Diabetes | 1.122 (0.458–2.753) | 0.801 | 1.044 (0.356–3.062) | 0.938 | 0.754 (0.276–1.919( | 0.553 | 1.237 (0.457–3.352) | 0.676 |
| Hypertension | 1.049 (0.388–2.838) | 0.925 | 0.664 (0.177–2.491) | 0.543 | 1.844 (0.106–32.123) | 0.675 | 0.578 (0.022–14.935) | 0.741 |
| Stroke | 4.364 (1.12–17.002) | 0.034 | 2.763 (0.818–9.327) | 0.102 | ||||
| TIA | 0.514 (0.106–2.498) | 0.409 | 0.787 (0.126–4.933) | 0.798 | ||||
| Atrial fibrillation | 0.920 (0.196–4.328) | 0.916 | 1.071 (0.195–5.877) | 0.937 | 1.453 (0.476–4.434) | 0.512 | 1.656 (0.559–4.901) | 0.363 |
| MI | 2.294 (0.901–5.839 | 0.082 | 0.949 (0.357–2.523) | 0.916 | ||||
| Cardiovascular disease | 0.970 (0.404–2.328) | 0.946 | 0.951 (0.353–2.566) | 0.921 | ||||
| Heart failure | 1.370 (0.564–3.329) | 0.488 | 1.311 (0.506–3.396) | 0.577 | ||||
| Peripheral vascular disease | 1.441 (0.528–3.935) | 0.476 | 1.287 (0.437–3.788) | 0.647 | ||||
| Chronic obstructive pulmonary disease | 1.199 (0.343–4.187) | 0.776 | 1.060 (0.213–5.263) | 0.943 | 0.678 (0.225–2.038) | 0.488 | 0.341 (0.081–1.435) | 0.142 |
| Anaemic | 0.613 (0.282–1.330) | 0.215 | 1.340 (0.514–3.491) | 0.550 | 1.549 (0.623–3.855) | 0.347 | 1.826 (0.682–4.889) | 0.231 |
| uPCR ≥70 g/mol | 1.122 (0.509–2.470) | 0.766 | 1.994 (0.721–5.516) | 0.184 | 1.161 (0.470–2.865) | 0.746 | 3.400 (1.165–9.920) | 0.025 |
| Fast progression (> −3 mL/min/ 1.73 m2/year) | 0.641 (0.282–1.461) | 0.290 | 1.190 (0.382–3.705) | 0.764 | 1.260 (0.306–5.185) | 0.749 | 1.328 (0.243–7.264) | 0.744 |
Psychodynamic medications included opiates, anticholinergics, benzodiazepines, antihistamines and neuropathic analgesic medications. uPCR, urinary protein:creatinine ratio; TIA, transient ischaemic attack. Fast progression was not adjusted for eGFR due to collinearity.