Table 2.
Enriched GO terms and involved genes
| ID | Description | Genes |
|---|---|---|
| Diabetic glomerular compartment | ||
|
| ||
| GO: 0031012 | Extracellular matrix | MMP7, LUM, SLPI, SFRP1, CXCL12, SERPINE2, ANXA2, SERPING1, GPC4, DCN, MXRA7, ANXA4, F3, CCN2, FGF1, NDNF |
| GO: 0062023 | Collagen-containing extracellular matrix | LUM, SLPI, SFRP1, CXCL12, SERPINE2, ANXA2, SERPING1, GPC4, DCN, MXRA7, ANXA4, F3, CCN2 |
| GO: 0072073 | Kidney epithelium development | PROM1, SFRP1, TFAP2B, CD24, SMAD5, EPHA7, KLHL3, FGF1, NPHS2 |
| GO: 0002237 | Response to molecule of bacterial origin | SLPI, VIM, CD24, ABCA1, HMGB2, DCN, LIAS, THBD, CEBPB, GCH1, NFKBIA, ADM |
| GO: 0098552 | Side of membrane | VTCN1, SERPINE2, ABCA1, GPC4, LDLR, IL1RL1, F3, HLA-DRB4, CD83, NPHS2, RGS2 |
| GO: 0009897 | External side of plasma membrane | VTCN1, SERPINE2, ABCA1, GPC4, LDLR, IL1RL1, F3, CD83 |
| GO: 0032496 | Response to lipopolysaccharide | SLPI, VIM, ABCA1, HMGB2, DCN, LIAS, THBD, CEBPB, GCH1, NFKBIA, ADM |
| GO: 0001655 | Urogenital system development | PROM1, SFRP1, TFAP2B, CD24, SMARCC1, DCN, SMAD5, EPHA7, KLHL3, FGF1, NPHS2 |
| GO: 0001822 | Kidney development | PROM1, SFRP1, TFAP2B, CD24, DCN, SMAD5, EPHA7, KLHL3, FGF1, NPHS2 |
| GO: 0072001 | Renal system development | PROM1, SFRP1, TFAP2B, CD24, DCN, SMAD5, EPHA7, KLHL3, FGF1, NPHS2 |
| GO: 0032103 | Positive regulation of response to external stimulus | CXCL12, STX3, NUPR1, CCL4, LDLR, THBD, IL1RL1, F3, CEBPB, NFKBIA |
| GO: 0045861 | Negative regulation of proteolysis | SLPI, WFDC2, SERPINE2, TFAP2B, SERPING1, SMARCC1, CSNK2A1, CAMLG, PLAUR, KLF4 |
| GO: 0016049 | Cell growth | SFRP1, CXCL12, SERPINE2, SORBS2, CSNK2A1, PAPPA2, TAF9B, EPHA7, IFRD1, SOCS2, SGK1, RGS2 |
| GO: 0001558 | Regulation of cell growth | SFRP1, CXCL12, SERPINE2, CSNK2A1, PAPPA2, TAF9B, EPHA7, IFRD1, SOCS2, SGK1, RGS2 |
| GO: 0001101 | Response to acid chemical | SFRP1, BCHE, UFL1, ABCA1, FABP3, LAMTOR3, LDLR, KLF4, CEBPB, CCN2 |
| GO: 0072009 | Nephron epithelium development | PROM1, TFAP2B, CD24, KLHL3, FGF1, NPHS2 |
| GO: 0032365 | Intracellular lipid transport | ANXA2, ABCA1, FABP3, LDLR |
| GO: 0045823 | Positive regulation of heart contraction | GCH1, CCN2, ADM, RGS2 |
| GO: 0030193 | Regulation of blood coagulation | SERPINE2, SERPING1, PLAUR, THBD, F3 |
| GO: 1900046 | Regulation of hemostasis | SERPINE2, SERPING1, PLAUR, THBD, F3 |
| GO : 0061318 | Renal filtration cell differentiation | PROM1, CD24, NPHS2 |
| GO: 0072112 | Glomerular visceral epithelial cell differentiation | PROM1, CD24, NPHS2 |
| GO: 0050818 | Regulation of coagulation | SERPINE2, SERPING1, PLAUR, THBD, F3 |
| GO: 0072311 | Glomerular epithelial cell differentiation | PROM1, CD24, NPHS2 |
| GO: 0030195 | Negative regulation of blood coagulation | SERPINE2, SERPING1, PLAUR, THBD |
| GO: 1900047 | Negative regulation of hemostasis | SERPINE2, SERPING1, PLAUR, THBD |
| GO : 0032373 | Positive regulation of sterol transport | ANXA2, ABCA1, NFKBIA |
| GO: 0032376 | Positive regulation of cholesterol Transport | ANXA2, ABCA1, NFKBIA |
| GO: 0072010 | Glomerular epithelium development | PROM1, CD24, NPHS2 |
| GO: 0052547 | Regulation of peptidase activity | SLPI, WFDC2, TFAP2B, CSNK2A1, EPHA7, PLAUR, KLF4, F3, PCOLCE2, CCN2 |
| Diabetic tubulointerstitial compartment | ||
|
| ||
| GO: 0044282 | Small molecule catabolic process | ENTPD1, IDUA, HYAL1, TST, IVD, GLS, ENPP4, ACOX1, MTRR, MCCC2, HADH, ENO1, ENTPD5, AHCY, HNMT, ECI2, PFKFB2, EHHADH, PEX7, ALDH7A1, ETFDH, DBT, ACADSB, CRYM, ACADM, PNP, IMPA1, ACADL, HAGH, KYNU, DECR2, MMUT, FUT6, KHK, RIDA, BCKDHB, MCCC1, GLUD2, AUH, GOT1, ALDH8A1, CRYL1, FAH, CTH, ALDH3A2, DERA, QDPR, ACAA1, HGD, UPB1, ALDH1L1, ALDH1B1, GK, KMO, NUDT3, ALDH6A1, QPRT, SORD, HADHA, ABAT, ACOX2, PRODH2, NPL, DPYS, FABP1 |
| GO: 0016054 | Organic acid catabolic process | IDUA, HYAL1, TST, IVD, GLS, ACOX1, MTRR, MCCC2, HADH, AHCY, HNMT, ECI2, EHHADH, PEX7, ALDH7A1, ETFDH, DBT, ACADSB, CRYM, ACADM, ACADL, KYNU, DECR2, MMUT, RIDA, BCKDHB, MCCC1, GLUD2, AUH, GOT1, ALDH8A1, CRYL1, FAH, CTH, ALDH3A2, QDPR, ACAA1, HGD, ALDH1L1, KMO, ALDH6A1, QPRT, SORD, HADHA, ABAT, ACOX2, PRODH2, NPL, FABP1 |
| GO: 0046395 | Carboxylic acid catabolic process | IDUA, HYAL1, TST, IVD, GLS, ACOX1, MTRR, MCCC2, HADH, AHCY, HNMT, ECI2, EHHADH, PEX7, ALDH7A1, ETFDH, DBT, ACADSB, CRYM, ACADM, ACADL, KYNU, DECR2, MMUT, RIDA, BCKDHB, MCCC1, GLUD2, AUH, GOT1, ALDH8A1, CRYL1, FAH, CTH, ALDH3A2, QDPR, ACAA1, HGD, ALDH1L1, KMO, ALDH6A1, QPRT, SORD, HADHA, ABAT, ACOX2, PRODH2, NPL, FABP1 |
| GO: 0050662 | Coenzyme binding | QSOX1, CYBB, MICAL2, IVD, IDH3G, ACOX1, MTRR, HADH, IDH2, AHCY, ECI2, GRHPR, PNPLA3, CAT, ETFDH, ACADSB, IDH3B, CRYM, MAOB, ACADM, ACADL, KYNU, AIFM1, P4HA2, CRYZL1, MARC2, MCCC1, GPHN, GOT1, CRYL1, HPGD, NOX4, CTH, IDH3A, DDC, AOX1, ALDH1B1, NQO2, KMO, ALDH6A1, SORD, GPD1, HADHA, ABAT, ACOT7, ACOX2, DHTKD1 |
| GO: 0048037 | Cofactor binding | LCN2, QSOX1, CYBB, PTGES, MICAL2, IVD, IDH3G, FDX1, ACLY, ACOX1, ACO2, MTRR, HADH, IDH2, AHCY, ECI2, GRHPR, PNPLA3, CAT, ETFDH, ACADSB, IDH3B, CRYM, MAOB, CYP11B2, ACADM, CYB5A, CYP20A1, ACADL, KYNU, AIFM1, P4HA2, MMUT, CRYZL1, ACO1, MARC2, MCCC1, GPHN, GOT1, CRYL1, HPGD, NOX4, CTH, SDHC, SDHB, IDH3A, DDC, AOX1, ALDH1B1, NQO2, KMO, ALDH6A1, GSTM4, SORD, GPD1, HADHA, ABAT, ACOT7, ACOX2, CUBN, DHTKD1, AOC1 |
| GO: 0006520 | Cellular amino acid metabolic process | TST, IVD, GLS, MTRR, MCCC2, AHCY, HNMT, NARS2, PSMA3, PSMD1, PSMF1, ALDH7A1, DBT, PSMD12, ACADSB, CRYM, PEPD, ADI1, EPRS, KYNU, MMUT, PSMD11, RIDA, BCKDHB, MCCC1, GLUD2, AUH, PSMC2, GOT1, NR1H4, ALDH8A1, NOX4, FAH, CTH, GLYAT, ASS1, DDC, BPHL, QDPR, HGD, UPB1, KMO, ALDH6A1, GCLM, DPEP1, ABAT, FOLH1B, BHMT2, PRODH2, PSAT1, DPYS, SLC7A7 |
| GO: 0009063 | Cellular amino acid catabolic process | TST, IVD, GLS, MTRR, MCCC2, AHCY, HNMT, ALDH7A1, DBT, ACADSB, CRYM, KYNU, RIDA, BCKDHB, MCCC1, GLUD2, AUH, GOT1, ALDH8A1, FAH, CTH, QDPR, HGD, KMO, ALDH6A1, ABAT, PRODH2 |
| GO: 0010038 | Response to metal ion | ITPR3, CAV1, CALR, FABP4, CYBB, B2M, MEF2C, LOXL2, HNRNPD, PTGES, ABCC2, HOMER1, NEDD4L, CREB1, PRKAA2, SLC30A5, SLC11A2, BNIP3, CAT, MT1E, MAOB, MT1X, CYP11B2, CYB5A, MT1H, ALAD, MT1G, MT1F, LGMN, ACO1, GPHN, GOT1, EGFR, GGH, ASS1, QDPR, PRNP, CLIC4, DPEP1, CA2, SORD, CPNE3, ABAT, AOC1 |
| GO: 1901605 | Alpha-amino acid metabolic process | IVD, GLS, MTRR, MCCC2, AHCY, HNMT, ALDH7A1, CRYM, ADI1, KYNU, MMUT, RIDA, MCCC1, GLUD2, AUH, GOT1, NR1H4, ALDH8A1, NOX4, FAH, CTH, GLYAT, ASS1, QDPR, HGD, KMO, ALDH6A1, GCLM, DPEP1, BHMT2, PRODH2, PSAT1 |
| GO: 0005777 | Peroxisome | ACSL4, PEX19, ACOX1, ACSL3, ISOC1, IDH2, ECI2, GRHPR, PLAAT3, EHHADH, PEX7, CAT, ACSL1, CRYM, DECR2, MARC2, RIDA, ALDH3A2, EPHX2, ACAA1, HSDL2, ACOX2, AOC1, FABP1 |
| GO: 0042579 | Microbody | ACSL4, PEX19, ACOX1, ACSL3, ISOC1, IDH2, ECI2, GRHPR, PLAAT3, EHHADH, PEX7, CAT, ACSL1, CRYM, DECR2, MARC2, RIDA, ALDH3A2, EPHX2, ACAA1, HSDL2, ACOX2, AOC1, FABP1 |
| GO: 0005759 | Mitochondrial matrix | ERBB4, ISCA1, TST, GRSF1, IVD, IDH3G, GLS, PDP1, FDX1, HSPD1, ACO2, MCCC2, HADH, IDH2, CREB1, NARS2, ACSS3, MRPL42, GRPEL1, ALDH7A1, ETFDH, DBT, MRPL22, MAIP1, ACADSB, IDH3B, VDAC1, ACADM, ACADL, LRPPRC, HAGH, MMUT, RIDA, BCKDHB, MCCC1, MRPS18B, AUH, FOXO3, GLYAT, IDH3A, DLAT, ALDH1B1, ALDH6A1, LACTB2, NR3C1, ACSF2, HADHA, ABAT, DHTKD1 |
| GO: 1901606 | Alpha-amino acid catabolic process | IVD, GLS, MTRR, MCCC2, AHCY, HNMT, ALDH7A1, CRYM, KYNU, RIDA, MCCC1, GLUD2, AUH, GOT1, ALDH8A1, FAH, QDPR, HGD, KMO, ALDH6A1, PRODH2 |
| GO: 0006732 | Coenzyme metabolic process | NNMT, PFKFB3, ACSL4, NUP214, FOLR2, CD38, NUP50, PDP1, ACLY, ACSL3, MTRR, MCCC2, IDH2, ENO1, ENTPD5, PFKFB2, MAT2A, PRKAA2, RFK, ZBTB7A, ACSL1, STAT3, PNP, CYB5A, KYNU, MOCS2, MCCC1, GPHN, AMD1, GLYAT, DERA, DLAT, ALDH1L1, KMO, ACOT13, ACSF2, QPRT, GPD1, ACOT7, AASDHPPT, BHMT2, DHTKD1, INSR |
| GO: 0006790 | Sulfur compound metabolic process | ACPP, ACSL4, CHST15, IDUA, BGN, MICAL2, HYAL1, TST, PDP1, ABCC2, ACLY, CIAO1, ACSL3, ARSB, ST3GAL1, MTRR, MCCC2, SULT1C2, AHCY, PAX8, MAT2A, ACSL1, ADI1, HAGH, KYNU, MMUT, MCCC1, NOX4, CTH, AMD1, GLYAT, DLAT, ACOT13, GNS, GSTM4, GCLM, ACSF2, DPEP1, ACOT7, BHMT2, SLC35D1 |
| GO: 0002283 | Neutrophil activation involved in immune response | LTF, C3, LCN2, ACPP, CD93, CFD, QSOX1, RNASET2, CYBB, B2M, LAIR1, RAB31, FCER1G, FCN1, MNDA, DNASE1L3, ATP6V1D, PGRMC1, ENPP4, RAB5C, ACLY, ARSB, CTSA, ILF2, CPPED1, DEGS1, PSMD1, CAT, IGF2R, CTSB, PSMD12, HMOX2, PNP, RAB14, ALAD, PSMD11, NRAS, PSMC2, METTL7A, RAB7A, GGH, LAMP2, DERA, MAGT1, ACAA1, SLC2A5, CMTM6, IQGAP2, GNS, CPNE3, AOC1 |
| GO: 0002446 | Neutrophil mediated immunity | LTF, C3, LCN2, ACPP, CD93, CFD, QSOX1, RNASET2, CYBB, B2M, LAIR1, RAB31, FCER1G, FCN1, MNDA, DNASE1L3, ATP6V1D, PGRMC1, ENPP4, RAB5C, ACLY, ARSB, CTSA, ILF2, CPPED1, DEGS1, PSMD1, CAT, IGF2R, CTSB, PSMD12, HMOX2, PNP, RAB14, ALAD, PSMD11, NRAS, PSMC2, METTL7A, RAB7A, GGH, LAMP2, DERA, MAGT1, ACAA1, SLC2A5, CMTM6, IQGAP2, GNS, CPNE3, AOC1 |
| GO: 0042119 | Neutrophil activation | LTF, C3, LCN2, ACPP, CD93, CFD, QSOX1, RNASET2, CYBB, B2M, LAIR1, RAB31, FCER1G, FCN1, MNDA, DNASE1L3, ATP6V1D, PGRMC1, ENPP4, RAB5C, ACLY, ARSB, CTSA, ILF2, CPPED1, DEGS1, PSMD1, CAT, IGF2R, CTSB, PSMD12, HMOX2, PNP, RAB14, ALAD, PSMD11, NRAS, PSMC2, METTL7A, RAB7A, GGH, LAMP2, DERA, MAGT1, ACAA1, SLC2A5, CMTM6, IQGAP2, GNS, CPNE3, AOC1 |
| GO: 0043312 | Neutrophil degranulation | LTF, C3, LCN2, ACPP, CD93, CFD, QSOX1, RNASET2, CYBB, B2M, LAIR1, RAB31, FCER1G, FCN1, MNDA, ATP6V1D, PGRMC1, ENPP4, RAB5C, ACLY, ARSB, CTSA, ILF2, CPPED1, DEGS1, PSMD1, CAT, IGF2R, CTSB, PSMD12, HMOX2, PNP, RAB14, ALAD, PSMD11, NRAS, PSMC2, METTL7A, RAB7A, GGH, LAMP2, DERA, MAGT1, ACAA1, SLC2A5, CMTM6, IQGAP2, GNS, CPNE3, AOC1 |
| GO: 0051287 | Nicotinamide adenine dinucleotide (NAD) binding | IDH3G, HADH, IDH2, AHCY, GRHPR, IDH3B, CRYL1, HPGD, IDH3A, AOX1, ALDH1B1, SORD, GPD1, HADHA |
| GO: 0050660 | Flavin adenine dinucleotide binding | QSOX1, CYBB, MICAL2, IVD, ACOX1, MTRR, ETFDH, ACADSB, MAOB, ACADM, AIFM1, NOX4, AOX1, NQO2, KMO, ACOX2 |
| GO: 0006631 | Fatty acid metabolic process | C3, ACSL4, CAV1, CD74, PTGES, RGN, IVD, PDP1, ACOX1, ACSL3, HADH, ECI2, PRKAA2, EHHADH, DEGS1, PNPLA3, PEX7, ETFDH, ACSL1, ACADSB, ACADM, ACADL, DECR2, MMUT, LYPLA1, CRYL1, HPGD, CES2, ALDH3A2, EPHX2, ACAA1, MSMO1, GSTM4, ACSF2, HADHA, ACOT7, ACOX2, QKI, FABP1 |
| GO: 0043202 | Lysosomal lumen | AGRN, RNASET2, CD74, IDUA, BGN, SGSH, HYAL1, CTSL, ARSB, CTSA, CTSB, TPP1, LGMN, GPC3, LAMP2, GNS, CUBN, CTSV |
| GO: 0016999 | Antibiotic metabolic process | CYBB, IDH3G, ABCC2, ADH5, ACLY, ST3GAL1, ACO2, IDH2, GPX3, CAT, STAT3, IDH3B, MAOB, ACO1, EGFR, SDHC, SDHB, IDH3A, DLAT, ALDH1B1, DPEP1, NPL |
| GO: 0044438 | Microbody part | ACSL4, PEX19, ACOX1, ACSL3, ECI2, GRHPR, PLAAT3, EHHADH, PEX7, CAT, ACSL1, CRYM, DECR2, ALDH3A2, EPHX2, ACAA1, ACOX2, FABP1 |
| GO: 0044439 | Peroxisomal part | ACSL4, PEX19, ACOX1, ACSL3, ECI2, GRHPR, PLAAT3, EHHADH, PEX7, CAT, ACSL1, CRYM, DECR2, ALDH3A2, EPHX2, ACAA1, ACOX2, FABP1 |
| GO: 0045177 | Apical part of cell | ANXA1, ITPR3, OXTR, PLAT, ABCC2, HOMER1, USH1C, SORBS2, SLC30A5, SLC11A2, PDZK1, SLC3A2, LRP2, ATP6V1C1, LGMN, ERBB3, STX3, NOX4, ABCC6, EZR, EGFR, SLC2A5, VAMP3, CLCN5, TUBG1, CLIC4, SLC22A4, SLC17A1, DPEP1, CA2, PRKCI, KL, SLC7A9, THY1, PODXL, CUBN, MTDH, CTSV, FABP1 |
| GO: 0031983 | Vesicle lumen | LTF, C3, LCN2, CFD, QSOX1, CALR, RNASET2, B2M, TOR4A, HGF, FCN1, MNDA, VEGFC, SERPINF2, ACLY, ARSB, CTSA, ILF2, CPPED1, PSMD1, CAT, PSMD12, PNP, ALAD, PSMD11, VEGFA, PSMC2, EGFR, GGH, DERA, ACAA1, KNG1, GNS, APOE, APOH, PLG, AOC1 |
| GO: 0072350 | Tricarboxylic acid metabolic process | IDH3G, ACLY, ACO2, IDH2, IDH3B, ACO1, SDHC, SDHB, IDH3A, ASS1, DLAT |
| GO: 0005775 | Vacuolar lumen | C3, AGRN, RNASET2, CD74, IDUA, BGN, MNDA, SGSH, HYAL1, CTSL, ACLY, ARSB, CTSA, CPPED1, PSMD1, CTSB, TPP1, LGMN, GPC3, GGH, LAMP2, GNS, CUBN, CTSV |