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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Comp Biochem Physiol C Toxicol Pharmacol. 2021 Mar 22;245:109034. doi: 10.1016/j.cbpc.2021.109034

Fig. 2.

Fig. 2.

Ancestral state reconstruction of coagulotoxicity in rattlesnakes (Crotalus + Sistrurus) as tested on human fibrinogen. Warmer colors indicate shorter clotting times, whereby fibrinogen was clotted in a pseudo-procoagulant manner whereas colder colors represent longer clotting times (no effect) relative to the negative control (999 s). Bars indicate 95% confidence intervals for the estimate at each node. Note: due to the high dynamicity of venom evolution, the node bar ranges quickly become broad as one moves down the tree. Maximum clotting time = 999 s. Values are mean (n = 4 ± SD). Organismal phylogenetic arrangements from Alencar et al. (2016) and timetree.org.