Table 4.

Options for intensification after basal insulin therapy.

Options	Efficacy	Hypos	Weight Change	Cost
Basal plus insulin regimen	Highest—with greater flexibility but increased complexity	+++	++	Depends on the insulin used
Premixed insulin regimen	Highest—low complexity but lesser flexibility	++	+	Depends on the insulin used
Adding GLP-1RA	High—with highest flexibility and least complexity	+	Reduction	High compared to other two regimens

CV: Cardiovascular; GLP-1RA: Glucagon-like peptide-1 receptor agonist.