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Transcriptional upregulation of Tfeb by aspirin via PPARα. Aspirin activates PPARα that binds to peroxisome proliferator response element (PPRE) present in Tfeb gene promoter and causes its transcription. Other members of the transcriptional complex are CREB-binding protein (CBP) and RNA polymerase II. TFEB is responsible for lysosomal biogenesis and autophagy.
