A, BMC distribution scatter plots showing BMC values for metabolomic features (blue squares), metabolomic LCRD values (green circles), transcriptomic features (red diamonds), transcriptomic LCRD values (light yellow triangles), therapeutic/normal blood levels (if available; orange sideways triangles) and toxic blood levels (if available; light blue sideways triangles). B, Metabolomic and transcriptomic LCRD range plot showing the 95% lower (BMCL) (circles) and upper bound (BMCU) (diamonds) around the BMC that corresponds to the LCRD (squares).